Rhea is an expert-curated knowledgebase of chemical and transport reactions of biological interest. Enzyme-catalyzed and spontaneously occurring reactions are curated from peer-reviewed literature and represented in a computationally tractable manner by using the ChEBI (Chemical Entities of Biological Interest) ontology to describe reaction participants.
Rhea covers the reactions described by the IUBMB Enzyme Nomenclature as well as many additional reactions and can be used for enzyme annotation, genome-scale metabolic modeling and omics-related analyses. Rhea is the standard for enzyme and transporter annotation in UniProtKB.
- Prefix
rhea- Alternative Prefixes
- RHEA
- Keywords
- biochemistry life science reaction small molecule
- License
- CC-BY-4.0
- Links
- Homepage
- Contact
- Anne Morgat 0000-0002-1216-2969
- Pattern for Local Unique Identifiers
-
Local identifiers in Rhea reaction should match this regular expression:
^\d{5}$ - Example Local Unique Identifier
- 12345 Resolve
- Pattern for CURIES
-
Compact URIs (CURIEs) constructed from Rhea reaction should match this regular expression:
^rhea:\d{5}$ - Example CURIE
- rhea:12345
- Publications
-
- 2022 Rhea, the reaction knowledgebase in 2022
- 2020 Enzyme annotation in UniProtKB using Rhea
- 2019 Updates in Rhea: SPARQLing biochemical reaction data
- 2016 Updates in Rhea - an expert curated resource of biochemical reactions
- 2014 Updates in Rhea--a manually curated resource of biochemical reactions
- 2011 Rhea--a manually curated resource of biochemical reactions
Metaregistry Rhea reaction
The metaregistry provides mappings between the Semantic Farm and other registries. There are 12 mappings to external registries for this resource with 7 unique external prefixes.
| Registry Name | Registry Metaprefix | External Prefix | Curate |
|---|---|---|---|
| BioContext | biocontext |
RHEA
|
|
EDAM
|
edam |
2644
|
|
FAIRSharing
|
fairsharing |
FAIRsharing.pn1sr5
|
|
GO
|
go |
RHEA
|
|
Integbio
|
integbio |
nbdc02083
|
|
Identifiers.org
|
miriam |
rhea
|
|
N2T
|
n2t |
rhea
|
|
Pathguide
|
pathguide |
310
|
|
Prefix Commons
|
prefixcommons |
rhea
|
|
re3data
|
re3data |
r3d100010891
|
|
| TogoID | togoid |
Rhea
|
|
Wikidata (E)
|
wikidata.entity |
Q24265951
|
Providers
A provider turns a local unique identifiers from a resource into a URI. Many providers are also resolvable as URLs (i.e., they can be used in a web browser).
The local unique identifier 12345 is used to demonstrate the providers
available for Rhea reaction. Some providers may use a different example, which is displayed in the table below.
A guide for curating additional providers can be found
here.
| Name | Metaprefix | URI |
|---|---|---|
| Rhea reaction | rhea |
https://www.rhea-db.org/rhea/12345 |
| Bioregistry | bioregistry |
https://bioregistry.io/rhea:12345 |
| Identifiers.org | miriam |
https://identifiers.org/rhea:12345 |
| Name-to-Thing | n2t |
https://n2t.net/rhea:12345 |
Extra Providers
Additional providers curated in the Semantic Farm are listed here. These are typically inherited from Identifiers.org or Prefix Commons, and need extra curation.
| Code | Name | URL |
|---|---|---|
bio2rdf |
Bio2RDF | http://bio2rdf.org/rhea:12345 |