{"prefix":"rhea","name":"Rhea reaction","description":"Rhea is an expert-curated knowledgebase of chemical and transport reactions of biological interest. Enzyme-catalyzed and spontaneously occurring reactions are curated from peer-reviewed literature and represented in a computationally tractable manner by using the ChEBI (Chemical Entities of Biological Interest) ontology to describe reaction participants.\n\nRhea covers the reactions described by the IUBMB Enzyme Nomenclature as well as many additional reactions and can be used for enzyme annotation, genome-scale metabolic modeling and omics-related analyses. Rhea is the standard for enzyme and transporter annotation in UniProtKB.","pattern":"^\\d{5}$","uri_format":"https://www.rhea-db.org/rhea/$1","providers":[{"code":"bio2rdf","name":"Bio2RDF","description":"Bio2RDF is an open-source project that uses Semantic Web technologies to build and provide the largest network of Linked Data for the Life Sciences. Bio2RDF defines a set of simple conventions to create RDF(S) compatible Linked Data from a diverse set of heterogeneously formatted sources obtained from multiple data providers.","homepage":"https://bio2rdf.org","uri_format":"http://bio2rdf.org/rhea:$1"}],"homepage":"https://www.rhea-db.org/","example":"12345","example_extras":[],"license":"CC-BY-4.0","download_owl":"https://w3id.org/biopragmatics/resources/rhea/rhea.owl.gz","download_obo":"https://w3id.org/biopragmatics/resources/rhea/rhea.obo","download_json":"https://w3id.org/biopragmatics/resources/rhea/rhea.json.gz","deprecated":false,"mappings":{"biocontext":"RHEA","edam":"2644","go":"RHEA","integbio":"nbdc02083","miriam":"rhea","n2t":"rhea","pathguide":"310","prefixcommons":"rhea","re3data":"r3d100010891","togoid":"Rhea","wikidata.entity":"Q24265951"},"synonyms":["RHEA"],"keywords":["biopax","interaction/pathway","metabolite","ontology","protein","reaction","small molecule"],"publications":[{"pubmed":"34755880","doi":"10.1093/nar/gkab1016","pmc":"PMC8728268","title":"Rhea, the reaction knowledgebase in 2022","year":2022},{"pubmed":"31688925","doi":"10.1093/bioinformatics/btz817","pmc":"PMC7162351","title":"Enzyme annotation in UniProtKB using Rhea","year":2020},{"pubmed":"30272209","doi":"10.1093/nar/gky876","pmc":"PMC6324061","title":"Updates in Rhea: SPARQLing biochemical reaction data","year":2019},{"pubmed":"27789701","doi":"10.1093/nar/gkw990","pmc":"PMC5210663","title":"Updates in Rhea - an expert curated resource of biochemical reactions","year":2016},{"pubmed":"25332395","doi":"10.1093/nar/gku961","pmc":"PMC4384025","title":"Updates in Rhea--a manually curated resource of biochemical reactions","year":2014},{"pubmed":"22135291","doi":"10.1093/nar/gkr1126","pmc":"PMC3245052","title":"Rhea--a manually curated resource of biochemical reactions","year":2011}],"appears_in":[],"depends_on":[],"namespace_in_lui":false,"preferred_prefix":"rhea","logo":"https://www.rhea-db.org/style/images/rhea_logo.png"}