CATH is a classification of protein structural domains. We group protein domains into superfamilies when there is sufficient evidence they have diverged from a common ancestor. CATH can be used to predict structural and functional information directly from protein sequence.

Prefix

cath

Keywords

3d structure annotation biology classification curated information evolution evolutionary biology protein sequence structure

Links

Homepage

Publications

1997 CATH--a hierarchic classification of protein domain structures

2024 CATH v4.4: major expansion of CATH by experimental and predicted structural data

2021 CATH: increased structural coverage of functional space

2019 CATH: expanding the horizons of structure-based functional annotations for genome sequences

2018 Gene3D: Extensive prediction of globular domains in proteins

2016 CATH: an expanded resource to predict protein function through structure and sequence

2016 Functional classification of CATH superfamilies: a domain-based approach for protein function annotation

2015 The history of the CATH structural classification of protein domains

2015 Functional classification of CATH superfamilies: a domain-based approach for protein function annotation

2014 CATH: comprehensive structural and functional annotations for genome sequences

2002 The CATH protein family database: a resource for structural and functional annotation of genomes

2024 CATH 2024: CATH-AlphaFlow Doubles the Number of Structures in CATH and Reveals Nearly 200 New Folds

Pattern for Local Unique Identifiers

Local unique identifiers in CATH Protein Structural Domain Superfamily should match this regular expression:
^[1-6]\.[0-9]+\.[0-9]+\.[0-9]+$

Example Local Unique Identifier

1.10.8.10   Resolve

Pattern for CURIES

Compact URIs (CURIEs) constructed from CATH Protein Structural Domain Superfamily should match this regular expression:
^cath:[1-6]\.[0-9]+\.[0-9]+\.[0-9]+$

Example CURIE

cath:1.10.8.10

Contact

Christine Orengo   0000-0002-7141-8936

Identifier Space Owner

University College London

A summary of the relations in the Semantic Farm schema can be found here.

Has Parts (bfo:0000051 )

cath.superfamily

In Collection (1)

Synapse.org external links

Mappings from records in Semantic Farm to external registries comprises the metaregistry. This resource has 8 mappings to external registries with 5 unique external prefixes.

A provider turns a local unique identifiers from a resource into a URI. Many providers are also resolvable as URLs (i.e., they can be used in a web browser).

The local unique identifier 1.10.8.10 is used to demonstrate the providers available for CATH Protein Structural Domain Superfamily. Some providers may use a different example, which is displayed in the table below. A guide for curating additional providers can be found here.

Additional providers curated in the Semantic Farm are listed here. These are typically inherited from Identifiers.org or Prefix Commons, and need extra curation.