The Structure-Function Linkage Database (SFLD) is a hierarchical classification of enzymes that relates specific sequence-structure features to specific chemical capabilities. It was developed by the Babbitt Laboratory in collaboration with the UCSF Resource for Biocomputing, Visualization, and Informatics. As of April 2019, the database is in static format, and will not be updated. [from https://interpro-documentation.readthedocs.io/en/latest/sfld.html, accessed March 18th, 2026]

Comment

This database is now part of InterPro

Prefix
sfld
Keywords
family and domain databases
Links
Homepage
Publications
https://bioregistry.io/pubmed:24271399
Identifier Standards
Pattern for Local Unique Identifiers

Local identifiers in Structure Function Linkage Database should match this regular expression:
^SFLDS\d+$

Example Local Unique Identifier
SFLDS00019   Resolve
Pattern for CURIES

Compact URIs (CURIEs) constructed from Structure Function Linkage Database should match this regular expression:
^sfld:SFLDS\d+$

Example CURIE
sfld:SFLDS00019
Contacts
Contact
Missing Contact
Contributors
submitter Charles Tapley Hoyt   0000-0003-4423-4370   cthoyt
Metaregistry Structure Function Linkage Database

The metaregistry provides mappings between the Semantic Farm and other registries. There are 1 mappings to external registries for this resource with 1 unique external prefixes.

Registry Name Registry Metaprefix External Prefix Curate
UniProt UniProt Cross-ref database logo uniprot DB-0220
Providers

A provider turns a local unique identifiers from a resource into a URI. Many providers are also resolvable as URLs (i.e., they can be used in a web browser).

The local unique identifier SFLDS00019 is used to demonstrate the providers available for Structure Function Linkage Database. Some providers may use a different example, which is displayed in the table below. A guide for curating additional providers can be found here.

Name Metaprefix URI
Structure Function Linkage Database sfld https://www.ebi.ac.uk/interpro/entry/sfld/SFLDS00019
Bioregistry bioregistry https://bioregistry.io/sfld:SFLDS00019