{"prefix":"ec","name":"Enzyme Nomenclature","description":"The Enzyme Nomenclature (also known as the Enzyme Commission Code) is a species-agnostic controlled vocabulary for specific enzymes and an associated hierarchical classification into 7 main categories.\n\nThe Enzyme Nomenclature is maintained by the [Nomenclature Committee](https://iubmb.org/about/committees/nomenclature-committee/) of the International Union of Biochemistry and Molecular Biology (IUBMB). A detailed history of the nomenclature since the 1950s can be found [here](https://iubmb.qmul.ac.uk/enzyme/history.html).\n\nThere are few notable resources providing access to the Enzyme Nomenclature:\n\n<table class=\"table table-striped\"><thead><tr><th>Website</th><th>Homepage</td><th>Notes</td></tr></thead><tbody><tr><td>ExplorEnz</td><td><a href=\"https://www.enzyme-database.org\">https://www.enzyme-database.org</a></td><td>This is the resource officially recommended by IUBMB</td></tr><tr><td>IUBMB (via by Queen Mary)</td><td><a href=\"https://iubmb.qmul.ac.uk/enzyme\">https://iubmb.qmul.ac.uk/enzyme</a></td><td>This is a web-based version of the <a href=\"https://archive.org/details/enzymenomenclatu0000inte_d6c2\">1992 publication</a>.</td></tr><tr><td>IntEnz</td><td><a href=\"https://www.ebi.ac.uk/intenz\">https://www.ebi.ac.uk/intenz</a></td><td>Shutdown in 2024</td></tr><tr><td>ExPaSy</td><td><a href=\"https://enzyme.expasy.org\">https://enzyme.expasy.org</a></td></tr><tr><td>EnzymePortal</td><td><a href=\"https://www.ebi.ac.uk/enzymeportal\">https://www.ebi.ac.uk/enzymeportal</a></td><td></td></tr></tbody></table>","pattern":"^\\d{1,2}(((\\.\\d{1,3}){1,3})|(\\.\\d+){2}\\.[nB]\\d{1,3}|\\.-\\.-\\.-|\\.\\d{1,3}\\.-\\.-|\\.\\d{1,3}\\.\\d{1,3}\\.-)?$","uri_format":"https://www.enzyme-database.org/query.php?ec=$1","rdf_uri_format":"https://purl.expasy.org/enzyme/EC/$1","providers":[{"code":"","name":"KEGG Ligand Database for Enzyme Nomenclature","description":"KEGG Ligand Database for Enzyme Nomenclature","homepage":"https://www.genome.jp/dbget-bin/www_bfind?enzyme","uri_format":"https://www.genome.jp/dbget-bin/www_bget?ec:$1"},{"code":"bio2rdf","name":"Bio2RDF","description":"Bio2RDF is an open-source project that uses Semantic Web technologies to build and provide the largest network of Linked Data for the Life Sciences. Bio2RDF defines a set of simple conventions to create RDF(S) compatible Linked Data from a diverse set of heterogeneously formatted sources obtained from multiple data providers.","homepage":"https://bio2rdf.org","uri_format":"http://bio2rdf.org/intenz:$1"},{"code":"enzymeportal","name":"EnzymePortal","description":" Enzyme Portal integrates publicly available information about enzymes, such as reaction mechanism, small-molecule chemistry, biochemical pathways and drug compounds.","homepage":"https://www.ebi.ac.uk/enzymeportal","uri_format":"https://www.ebi.ac.uk/enzymeportal/ec/$1","publications":[{"pubmed":"28158609","doi":"10.1093/protein/gzx008","pmc":"PMC5421622","title":"An update on the Enzyme Portal: an integrative approach for exploring enzyme knowledge","year":2017}]},{"code":"expasy","name":"Enzyme nomenclature database, ExPASy (Expert Protein Analysis System)","description":"Enzyme nomenclature database, ExPASy (Expert Protein Analysis System)","homepage":"https://enzyme.expasy.org/","uri_format":"https://enzyme.expasy.org/EC/$1"}],"homepage":"https://www.enzyme-database.org/","contact":{"name":"Kristian Axelsen","orcid":"0000-0003-3889-2879","email":"kristian.axelsen@sib.swiss","github":"kaxelsen"},"owners":[{"ror":"00910ay07","name":"International Union of Biochemistry and Molecular Biology","partnered":false}],"example":"1.1.1.1","example_extras":["2","2.-.-.-","2.3","2.3.-.-","2.3.1","2.3.1.-","2.3.1.n12","3.1.26.n2","3.4.24.B15"],"example_decoys":["100","2.","2.n1","2.3.","2.3.n1","2.3.1.","2.3.1.n","2.3.4.1.","2.-.-","2.-","2.3.4.1.-"],"license":"CC-BY-4.0","download_owl":"https://w3id.org/biopragmatics/resources/ec/ec.owl","download_obo":"https://w3id.org/biopragmatics/resources/ec/ec.obo","download_json":"https://w3id.org/biopragmatics/resources/ec/ec.json","deprecated":false,"mappings":{"bartoc":"671","biocontext":"EC-CODE","edam":"1011","fairsharing":"FAIRsharing.rfLD2u","go":"EC","integbio":"nbdc00508","miriam":"ec-code","n2t":"ec-code","ols":"ec","pathguide":"106","prefixcommons":"intenz","re3data":"r3d100010803","togoid":"Ec","uniprot":"DB-0024","wikidata":"P591","wikidata.entity":"Q741108"},"synonyms":["EC","EC number","EC-CODE","ECCODE","EC_CODE","ec-code","eccode","intenz"],"keywords":["biochemistry","biopax","centrally registered identifier","classification","enzyme","enzyme and pathway databases","enzyme commission number","enzymology","function","ontology","ontology/terminology/nomenclature","protein","repository","rna"],"references":["https://github.com/biopragmatics/bioregistry/issues/681","https://github.com/biopragmatics/bioregistry/pull/1611"],"publications":[{"pubmed":"28158609","doi":"10.1093/protein/gzx008","pmc":"PMC5421622","title":"An update on the Enzyme Portal: an integrative approach for exploring enzyme knowledge","year":2017},{"pubmed":"14681451"},{"pubmed":"10592255","doi":"10.1093/nar/28.1.304","pmc":"PMC102465","title":"The ENZYME database in 2000","year":2000}],"appears_in":[],"depends_on":[],"namespace_in_lui":false,"comment":"The Nomenclature Committee website does not yet contain an official policy regarding the use of dashes in the hierarchical categorization of enzymes, so the Bioregistry's regular expression is permissive and accepts both EC identifiers with dashes (e.g. <code>2.3.-.-</code>) and without dashes (e.g., <code>2.3</code>). This means you may have to do post-processing of EC identifiers in data integration scenarios.","preferred_prefix":"EC","logo":"https://www.enzyme-database.org/images/banner_5.gif"}