{"prefix":"cog.cluster","name":"Cluster of orthologous genes","description":"COGs stands for Clusters of Orthologous Genes. The database was initially created in 1997 (Tatusov et al., PMID: 9381173) followed by several updates, most recently in 2014 (Galperin et al., PMID: 25428365). The current update includes complete genomes of 1,187 bacteria and 122 archaea that map into 1,234 genera. The new features include ~250 updated COG annotations with corresponding references and PDB links, where available; new COGs for proteins involved in CRISPR-Cas immunity, sporulation, and photosynthesis, and the lists of COGs grouped by pathways and functional systems.","pattern":"^COG\\d+$","uri_format":"https://www.ncbi.nlm.nih.gov/research/cog/cog/$1","providers":[{"code":"bio2rdf","name":"Bio2RDF","description":"Bio2RDF is an open-source project that uses Semantic Web technologies to build and provide the largest network of Linked Data for the Life Sciences. Bio2RDF defines a set of simple conventions to create RDF(S) compatible Linked Data from a diverse set of heterogeneously formatted sources obtained from multiple data providers.","homepage":"https://bio2rdf.org","uri_format":"http://bio2rdf.org/cog:$1"}],"homepage":"https://www.ncbi.nlm.nih.gov/research/cog/","contact":{"name":"Michael Y Galperin","orcid":"0000-0002-2265-5572","email":"cogs@ncbi.nlm.nih.gov"},"owners":[{"ror":"https://ror.org/02meqm098","name":"National Center for Biotechnology Information"}],"example":"COG0001","example_extras":[],"deprecated":false,"mappings":{"biolink":"COG","go":"COG_Cluster","miriam":"cog","prefixcommons":"cog","togoid":"Cog"},"synonyms":["COG_Cluster","cog"],"keywords":["genome","ortholog","protein"],"publications":[{"pubmed":"9381173","doi":"10.1126/science.278.5338.631","title":"A genomic perspective on protein families","year":1997},{"pubmed":"25428365","doi":"10.1093/nar/gku1223","pmc":"PMC4383993","title":"Expanded microbial genome coverage and improved protein family annotation in the COG database","year":2014}],"appears_in":[],"depends_on":[],"namespace_in_lui":false,"contributor":{"name":"Charles Tapley Hoyt","orcid":"0000-0003-4423-4370","email":"cthoyt@gmail.com","github":"cthoyt"},"preferred_prefix":"cog.cluster"}